Simultaneous occurrence of acute myeloblastic leukaemia and multiple myeloma without previous chemotherapy.
نویسندگان
چکیده
The simultaneous detection of multiple myeloma and acute myeloblastic leukaemia is reported in two patients who had not undergone chemotherapy. Histological examinations confirmed the infiltration by both myeloblasts and plasma cells. Only the latter contained monoclonal immunoglobulin chains at immunofluorescent studies. The possible relation between the two distinct proliferative processes is briefly discussed.
منابع مشابه
[Simultaneous occurrence of multiple myeloma and acute myeloid leukemia without previous chemotherapy].
Multiple myeloma and acute leukemia may sometimes occur in the same patient, usually in patients with myeloma who receive chemotherapy and subsequently develop acute leukemia. However, simultaneous occurrence of myeloma and acute leukemia on presentation is rare, with only a handful of such cases reported in the literature.
متن کاملSecondary acute lymphoblastic leukaemia in a multiple myeloma patient
Secondary acute leukaemia (s-ALL) is a destructive complication in patients who have been previously treated for other cancer. Secondary acute lymphoblastic leukaemia is rarely reported whereas secondary acute myeloid leukaemia is much more common. Chromosomal 11q23 abnormality, frequently detected in therapy-related acute myeloid leukaemia, is the most common cytogenetic alteration in secondar...
متن کاملPrognosis of Down's syndrome with acute leukaemia.
The outcome in children with acute leukaemia with (n = 90) and without Down's syndrome (n = 4377) was compared. Sixty three (70%) of those with Down's syndrome had acute lymphoblastic leukaemia and in comparison with 3664 (84%) controls had similar prognostic features except for a significant excess of the 'common' immunological subtype of acute lymphoblastic leukaemia. The outcome of the child...
متن کاملMetronomic Maintenance Therapy in Refractory Acute Myeloblastic Leukemia with Monosomy 7
Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we repo...
متن کاملRisk of acute myeloid leukaemia and multiple myeloma in workers exposed to benzene.
OBJECTIVE To determine the risk of developing acute myeloid leukaemia (AML) and multiple myeloma in a cohort of workers exposed to benzene. The results were used to show the importance of taking specificity of disease into consideration in causation analysis. METHODS Data were derived from a cohort of workers employed at two Goodyear plants in Ohio in the manufacture of Pliofilm. Based on dat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 2 5920 شماره
صفحات -
تاریخ انتشار 1974